Fibromyalgia causes suffering from musculoskeletal pain. This medical condition comes with sleep issues and fatigue, as well as mood issues due to the brain’s incapability to process pain signals. This is caused by several factors, which could be based in genetics, physical trauma, emotional trauma and even infections. When a person has been diagnosed with fibromyalgia, treatments like pain relievers, anti-seizure drugs (gabapentin and pregabalin), and antidepressants (nortriptyline, amitriptyline, paroxetine, etc.) are the most commonly recommended. However, few people are familiar with a certain type of Mucokinetics medication called guaifenesin. This incredible medication has many more benefits than antidepressants. For instance, it causes fewer side effects and can be bought over the counter (e.g., the brand name Mucinex).

In essence, guaifenesin is commonly used as an expectorant, which is basically a medication used to bring up mucus from the lungs, trachea and bronchi. Amazingly, this medication is also used to treat fibromyalgia. In 1995, researcher and clinician for fibromyalgia, Dr. Robert Bennett, and his technical advisor, Dr. St. Amand, discovered important points about guaifenesin. They are as follows:

1. Guaifenesin affects the nervous system of a patient with fibromyalgia.

Guaifenesin affects the nervous system of the body by working as a skeletal muscle relaxant. This medication is believed to treat fibromyalgia in that it depresses the transmission of nerve impulses in the central nervous system. Its effect was found due to the study of mephenesin, which had been found in the line of propanediol derivatives, a group of drugs that causes muscle relaxant effects. When further studies were conducted, compared to other medications, guaifenesin was shown to have less hemolytic activity, despite its greater water solubility. This makes it the most suitable drug for inducing skeletal muscle paralysis, a symptom present in fibromyalgia patients.

2. Guaifenesin has an anticoagulant effect useful for fibromyalgia patients.

Guaifenesin also has an anticoagulant effect, which is believed to be beneficial in treating people with fibromyalgia. The anticoagulant effect of guaifenesin was long discovered by Dr. John Couvaras after studying patients with fibromyalgia. Recently, a study was conducted that defined the anticoagulant effect of guaifenesin for fibromyalgia. The study revealed that some fibromyalgia symptoms correlate with higher levels of plasma serotonin and lower levels of serum serotonin. For instance, hypoglycemia is a related condition to serotonin and is very common in fibromyalgia.

3. Guaifenesin has an analgesic effect for patients suffering from fibromyalgia.

Researchers also studied mephenesin, which is a medication that has similar effects to guaifenesin. Like guaifenesin, mephenesin is extremely helpful in increasing the levels of amino acid glycine in the body. This medication has antagonistic effects and seems to excite amino acids’ effects. When compared to patients taking guaifenesin, researchers found that it too raised the levels of excitatory amino acids. In addition, felbamate, mephenesin was later discovered to inhibit NMDA neuron receptor activity, which is believed to help in treating pain associated with fibromyalgia. Therefore, mephenesin and guaifenesin has shown great potential in its ability to treat the pain levels of fibromyalgia.

4. Guaifenesin is a safe drug.

Guaifenesin is a grandfathered drug so it was not been a subject of thorough research in the past. Grandfathered drugs are drugs that were approved before 1938. This class of drugs was approved although the FDA didn’t agree with this classification. You see, the FDB thought that they differed from other versions of the drug in relevance to dosage, formulation, labeling and indications. That said, there has been no evidence to suggest that guaifenesin causes long-term effects or that it is carcinogenic. Even pregnant women are advised to take guaifenesin, which means that the drug is safe. Thus, this over-the-counter drug is claimed to have no side effects upon recommended use, and is safe for children.

5. FM patients testify the effectiveness of guaifenesin to fibromyalgia.

Even patients who used guaifenesin for fibromyalgia in the past set a higher rating of eight and above, or 40 people out of 53 patients testified the effectiveness of the drug for the condition. Only seven or 14% among the patients rated it lower than five. Patients also said that many years of use of guaifenesin for fibromyalgia helped them recover almost immediately and showed a great difference in mobility and activities. This survey explains the actual effectiveness of guaifenesin in fibromyalgia patients.

Thus, the direct relation of guaifenesin to fibromyalgia should not be questioned. Furthermore, fibromyalgia is not a simple disease, just as guaifenesin is not a simple drug. Fibromyalgia is a syndrome of symptoms and, in order to relieve the pain associated with it, why not try guaifenesin for help? Treating the source of pain can possibly reduce fibromyalgia symptoms.

334 [meds]” by eblaser is licensed under CC BY

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